Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as
rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues …

Monocytes are considered to be precursor cells of the mononuclear phagocytic system, and
macrophages are one of the leading members of this cellular system. Macrophages play …

Macrophages tailor their function according to the signals found in tissue
microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of …

The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells
under different environmental stimuli. Bone-resorbing osteoclasts are derived from the …

Objective. To evaluate efficacy and safety, baricitinib [Janus kinase (JAK) 1/JAK2 inhibitor]
was compared with placebo in Japanese patients with active rheumatoid arthritis (RA) …

The concept of immunological memory was demonstrated in antiquity when protection
against re-exposure to pathogens was observed during the plague of Athens …

Objective The nonresolving character of synovial inflammation in rheumatoid arthritis (RA) is
a conundrum. To identify the contribution of fibroblast‐like synoviocytes (FLS) to the …