Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

Cisplatin-induced hearing loss is a common side effect of cancer chemotherapy in clinics;
however, the mechanism of cisplatin-induced ototoxicity is still not completely clarified …

Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss.
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …

Despite the high incidence of inner ear disorders, there are still no dedicated medications on
the market. Drugs are currently administered by the intratympanic route, the safest way to …

The ototoxic side effect of cisplatin is a main cause of sensorineural hearing loss. This side
effect limits the clinical application of cisplatin and affects patients' quality of life. This study …

Introduction Cisplatin is a highly effective chemotherapeutic agent against a variety of solid
tumors in adults and in children. Unfortunately, a large percentage of patients suffer …

The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair
cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP …

Pure-tone thresholds have long served as a gold standard for evaluating hearing sensitivity
and documenting hearing changes related to medical treatments, toxic or otherwise …