Uveal melanoma is the most common primary malignant tumor of the eye in adults,
predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet …

Tumors require a blood supply for growth and hematogenous dissemination. Much attention
has been focused on the role of angiogenesis—the recruitment of new vessels into a tumor …

Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential
immunotherapies in cancer,. PD-L1 has been detected in the nucleus in multiple …

The term vasculogenic mimicry describes the formation of fluid‐conducting channels by
highly invasive and genetically dysregulated tumor cells. Two distinctive types of …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

purpose. To investigate the hypothesis that tumor-infiltrating macrophages contribute to
prognosis of uveal melanoma and to study their association with tumor characteristics …

Simple Summary Uveal melanoma is the most prevalent intraocular tumor in adults, derived
from melanocytes; the liver is the most common site of its metastases. Due to troublesome …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

The vitronectin receptor integrin αvβ3 promotes angiogenesis by mediating migration and
proliferation of endothelial cells, but also drives fibrogenic activation of hepatic stellate cells …

The eye and the brain are prototypical tissues manifesting immune privilege (IP) in which
immune responses to foreign antigens, particularly alloantigens are suppressed, and even …