Synaptic tau: A pathological or physiological phenomenon?

M Robbins, E Clayton, GS Kaminski Schierle - Acta Neuropathologica …, 2021 - Springer
In this review, we discuss the synaptic aspects of Tau pathology occurring during
Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark …

[HTML][HTML] Myocyte enhancer factor 2A plays a central role in the regulatory networks of cellular physiopathology

B Liu, WC Ou, L Fang, CW Tian, Y Xiong - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cell regulatory networks are the determinants of cellular homeostasis. Any alteration to
these networks results in the disturbance of cellular homeostasis and induces cells towards …

[HTML][HTML] The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons

B Zhu, RE Carmichael, LS Valois, KA Wilkinson… - Biochemical and …, 2018 - Elsevier
Neural stem cells (NSCs) are self-renewing multipotent stem cells that can be proliferated in
vitro and differentiated into neuronal and/or glial lineages, making them an ideal model to …

Modular Tunable α‐Helical Peptide Hydrogels for Neuronal Cells

DA Scott, A Wasmuth, E Abelardo… - Advanced Functional …, 2025 - Wiley Online Library
The assembly of synthetic modules into user‐defined hydrogels for cell culture and clinical
applications carries significant advantages over naturally derived materials. Modularity is …

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

A Fletcher-Jones, KL Hildick, AJ Evans, Y Nakamura… - Elife, 2019 - elifesciences.org
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it
downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is …

The mGluR5‐mediated Arc activation protects against experimental traumatic brain injury in rats

T Chen, YF Li, X Ren, YH Wang - CNS Neuroscience & …, 2024 - Wiley Online Library
Introduction Traumatic brain injury (TBI) is a complex pathophysiological process, and
increasing attention has been paid to the important role of post‐synaptic density (PSD) …

Protein SUMOylation regulates insulin secretion at multiple stages

JS Davey, RE Carmichael, TJ Craig - Scientific reports, 2019 - nature.com
Abstract Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues
of modern times, consuming 12% of worldwide health budgets and affecting an estimated …

Phosphorylation of Syntaxin‐1a by casein kinase 2α regulates pre‐synaptic vesicle exocytosis from the reserve pool

V Shi, TJ Craig, P Bishop, Y Nakamura… - Journal of …, 2021 - Wiley Online Library
The t‐soluble NSF‐attachment protein receptor protein Syntaxin‐1a (Stx‐1a) is abundantly
expressed at pre‐synaptic terminals where it plays a critical role in the exocytosis of …

[HTML][HTML] Endocytosis, trafficking and exocytosis of intact full-length botulinum neurotoxin type a in cultured rat neurons

LS Valois, KA Wilkinson, Y Nakamura, JM Henley - Neurotoxicology, 2020 - Elsevier
Abstract Botulinum toxin A (BoNT/A) is a potent neurotoxin that acts primarily by silencing
synaptic transmission by blocking neurotransmitter release. BoNT/A comprises a light chain …

Using lentiviral shRNA delivery to Knock down proteins in cultured neurons and in vivo

KA Wilkinson, KJ McMillan, PJ Banks… - … research methods in …, 2022 - Springer
Primary cultured neurons represent a benchmark preparation for studying neuronal cell
biology. However, due to their poor transfection efficiency, studies often require virus …