Gut microbiome immaturity and childhood acute lymphoblastic leukaemia

I Peppas, AM Ford, CL Furness, MF Greaves - Nature Reviews Cancer, 2023 - nature.com
Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …

Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low-to middle-income countries: A systematic review

CC Luchen, M Chibuye, R Spijker, M Simuyandi… - PLoS …, 2023 - journals.plos.org
Background Inappropriate antimicrobial usage is a key driver of antimicrobial resistance
(AMR). Low-and middle-income countries (LMICs) are disproportionately burdened by AMR …

[HTML][HTML] Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment

CMK Lynch, CSM Cowan, TFS Bastiaanssen… - Brain, Behavior, and …, 2023 - Elsevier
Numerous studies have emphasised the importance of the gut microbiota during early life
and its role in modulating neurodevelopment and behaviour. Epidemiological studies have …

Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk

DLY Dai, C Petersen, C Hoskinson, KL Del Bel… - Med, 2023 - cell.com
Background Early antibiotic exposure is linked to persistent disruption of the infant gut
microbiome and subsequent elevated pediatric asthma risk. Breastfeeding acts as a primary …

Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring

C Morel, IM Sanchez, Y Cherifi, N Chartrel… - Neuropharmacology, 2023 - Elsevier
The gut microbiota is increasingly recognized as a key environmental factor that shapes host
development and physiology, including neural circuits formation and function. Concurrently …

Effect of antibiotics on the human microbiome: A systematic review

KN Van Zyl, SR Matukane, BL Hamman… - International journal of …, 2022 - Elsevier
Background Global antibiotic use has been increasing for decades. The gut microbiome, a
key contributor to health, can be altered by antibiotics, which have been associated with …

Homeostasis and dysbiosis of the intestinal microbiota: comparing hallmarks of a healthy state with changes in inflammatory bowel disease

J Talapko, A Včev, T Meštrović, E Pustijanac, M Jukić… - Microorganisms, 2022 - mdpi.com
The gut microbiota, which represent a community of different microorganisms in the human
intestinal tract, are crucial to preserving human health by participating in various …

[HTML][HTML] The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

MA Lynn, G Eden, FJ Ryan, J Bensalem, X Wang… - Cell Reports, 2021 - cell.com
Studies investigating whether there is a causative link between the gut microbiota and
lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan …

Nasal bacterial microbiome differs between healthy controls and those with asthma and allergic rhinitis

M Chen, S He, P Miles, C Li, Y Ge, X Yu… - Frontiers in cellular …, 2022 - frontiersin.org
Perturbation of the microbiome has numerous associations with the phenotypes and
progression in chronic airways disease. However, the differences in the nasal microbiome in …

Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis

A Di Sabatino, G Santacroce, CM Rossi… - Internal and Emergency …, 2023 - Springer
The intestinal mucosa represents the most extensive human barrier having a defense
function against microbial and food antigens. This barrier is represented externally by a …