Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing
wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis …

Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

Horizontal gene transfer plays a major role in microbial evolution, allowing microbes to
acquire new genes and phenotypes. Integrative and conjugative elements (ICEs, aka …

In both humans and animals, Clostridium perfringens is an important cause of histotoxic
infections and diseases originating in the intestines, such as enteritis and enterotoxemia …

Conjugation of DNA through a type IV secretion system (T4SS) drives horizontal gene
transfer. Yet little is known on the diversity of these nanomachines. We previously found that …

The bacterial type IV secretion systems (T4SSs) comprise a biologically diverse group of
translocation systems functioning to deliver DNA or protein substrates from donor to target …

Bacterial conjugation presents the most important means to spread antibiotic resistance and
virulence factors among closely and distantly related bacteria. Conjugative plasmids are the …

Horizontal gene transfer plays a profound role in bacterial evolution by propelling the rapid
transfer of genes and gene cassettes. Integrative and conjugative elements (ICEs) are one …

Clostridium perfringens relies upon plasmid-encoded toxin genes to cause intestinal
infections. These toxin genes are associated with insertion sequences that may facilitate …

Abstract The Gram-positive pathogen Clostridium perfringens possesses a family of large
conjugative plasmids that is typified by the tetracycline resistance plasmid pCW3. Since …