An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium

FT Hansen, DM Gardiner, E Lysøe, PR Fuertes… - Fungal genetics and …, 2015 - Elsevier
Members of the genus Fusarium produce a plethora of bioactive secondary metabolites,
which can be harmful to humans and animals or have potential in drug development. In this …

Siderophores; iron scavengers: the novel & promising targets for pathogen specific antifungal therapy

M Balhara, R Chaudhary, S Ruhil, B Singh… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: The recent emergence of resistance, toxicity paradigm and limited efficacy of
conventional antifungal drugs necessitate the identification of de novo targets in fungal …

Identification of non-ribosomal peptide synthetase in Ganoderma boninense Pat. that was expressed during the interaction with oil palm

N Shokrollahi, CL Ho, NAIM Zainudin, MABA Wahab… - Scientific Reports, 2021 - nature.com
Basal stem rot (BSR) of oil palm is a disastrous disease caused by a white-rot fungus
Ganoderma boninense Pat. Non-ribosomal peptides (NRPs) synthesized by non-ribosomal …

Cyclic, Hydrophobic Hexapeptide Fusahexin Is the Product of a Nonribosomal Peptide Synthetase in Fusarium graminearum

KR Westphal, S Bachleitner… - Journal of Natural …, 2021 - ACS Publications
The plant pathogenic fungus Fusarium graminearum is known to produce a wide array of
secondary metabolites during plant infection. This includes several nonribosomal peptides …

High‐affinity iron uptake is required for optimal Epichloë festucae colonization of Lolium perenne and seed transmission

W Zhang, NT Forester, ER Applegate… - Molecular Plant …, 2023 - Wiley Online Library
Epichloë festucae uses a siderophore‐mediated system to acquire iron, which is important
to maintain endophyte–grass symbioses. Here we investigate the roles of the alternative iron …

High sulfate concentration enhances iron mobilization from organic soil to water

C Björnerås, M Škerlep, D Floudas, P Persson… - Biogeochemistry, 2019 - Springer
Widespread increases in iron (Fe) concentrations are contributing to ongoing browning of
northern freshwaters, but the driver/s behind the trends are not known. Fe mobilization in …

De Novo Assembly and Genome Analyses of the Marine-Derived Scopulariopsis brevicaulis Strain LF580 Unravels Life-Style Traits and Anticancerous Scopularide …

A Kumar, B Henrissat, M Arvas, MF Syed, N Thieme… - PLoS …, 2015 - journals.plos.org
The marine-derived Scopulariopsis brevicaulis strain LF580 produces scopularides A and B,
which have anticancerous properties. We carried out genome sequencing using three next …

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis

MB Lukassen, W Saei, TE Sondergaard, A Tamminen… - Marine drugs, 2015 - mdpi.com
Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived
Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3 …

Fungal secondary metabolites in the “OMICS” Era

S Zeilinger, C García-Estrada, JF Martín - Biosynthesis and Molecular …, 2015 - Springer
Secondary metabolites produced by fungi have a tremendous impact on the human society;
some are exploited for their antibiotic and pharmaceutical activities, others are involved in …

Distribution and Evolution of Nonribosomal Peptide Synthetase Gene Clusters in the Ceratocystidaceae

M Sayari, MA van Der Nest, ET Steenkamp, NC Soal… - Genes, 2019 - mdpi.com
In filamentous fungi, genes in secondary metabolite biosynthetic pathways are generally
clustered. In the case of those pathways involved in nonribosomal peptide production, a …