Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Immunosenescence, aging and successful aging

Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

[HTML][HTML] Frailty and sarcopenia: the potential role of an aged immune system

D Wilson, T Jackson, E Sapey, JM Lord - Ageing research reviews, 2017 - Elsevier
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

[PDF][PDF] Aging and the immune system: the impact of immunosenescence on viral infection, immunity and vaccine immunogenicity

CX Chan, YO Yang, GHM Cheng, SK Gera… - Immune …, 2019 - synapse.koreamed.org
Background Prophylactic pinning of the uninvolved side after unilateral slipped capital
femoral epiphysis (SCFE) is controversial. The alpha angle, a measurement of femoral head …

Age-dependent dysregulation of innate immunity

AC Shaw, DR Goldstein, RR Montgomery - Nature Reviews …, 2013 - nature.com
As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Neutrophils in aging and aging‐related pathologies

K Van Avondt, JK Strecker, C Tulotta… - Immunological …, 2023 - Wiley Online Library
Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Sex, the aging immune system, and chronic disease

MRG Bupp - Cellular immunology, 2015 - Elsevier
The immune systems of men and women differ in significant ways, especially after puberty.
In particular, females are generally more prone to autoimmunity, but experience lower rates …

Aging, inflammation, immunity and periodontal disease

JL Ebersole, CL Graves, OA Gonzalez… - Periodontology …, 2016 - Wiley Online Library
The increased prevalence and severity of periodontal disease have long been associated
with aging, such that this oral condition affects the majority of the adult population over 50 …