A ubiquitously expressed cytokine, transforming growth factor-beta (TGF-β) plays a
significant role in various ongoing cellular mechanisms. The gain or loss-of-function of TGF …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

The forkhead box O (FOXO) transcription factors (TFs) family are frequently mutated,
deleted, or amplified in various human cancers, making them attractive candidates for …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are
highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for …

Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view
on intracellular triglyceride (TG) mobilization–a process termed lipolysis. ATGL initiates the …

Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the
fourth most frequent cause of death having an oncological origin. It has been found that …

Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …