Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets
rich in fruits and vegetables confer protection against cardiovascular, neurodegenerative …

The cytosolic glutathione S-transferases are a family of structurally homologous enzymes
with multiple functions, including xenobiotic detoxification, clearance of oxidative stress …

Abstract Glutathione-S-transferases (GSTs) are one of the key enzymes that mediate phase
II of cellular detoxification. The aim of our study was a comprehensive characterization of …

Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the
activity and/or expression of glutathione S-transferases (GSTs). Because GSTs play a crucial …

In isothermal titration calorimetry, the statistical precisions with which the equilibrium
constant (K) and reaction enthalpy (Δ H°) can be estimated from data for 1: 1 binding …

Initial-rate and product inhibition studies revealed distinctive ordered ternary complex kinetic
mechanisms, substrate specificities, and metal ion preferences for the three isozymes of …

The market for commercially available isothermal titration calorimeters continues to grow as
new applications and methodologies are developed. Concomitantly the number of users …

Flavin mononucleotide adenylyltransferase (FMNAT) catalyzes the formation of the essential
flavocoenzyme flavin adenine dinucleotide (FAD) and plays an important role in …

Benzyl isothiocyanate (BITC), present in cruciferous vegetables, is an efficient substrate of
human glutathione S-transferase P1-1 (hGST P1-1). BITC also acts as an affinity label of …

Glutathione S-transferase (GST) is a potential therapeutic drug target against helminthic
diseases. This essential enzyme prevents oxidative stress by inhibiting the toxic build-up of …