Vincristine (VCR) is the first-line chemotherapeutic medication often co-administered with
other drugs to treat childhood acute lymphoblastic leukemia. Dose-dependent neurotoxicity …

Background: Vincristine (VCR) is a standard component in the treatment of childhood acute
lymphoblastic leukemia (ALL). VCR cytotoxicity is primarily due to its ability to disrupt the …

Many nitrogen-moiety containing alkaloids derived from plant origins are bioactive and play
a significant role in human health and emerging medicine. Noscapine, a …

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the
pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect …

Background Cancer, the second leading cause of death worldwide following cardiovascular
diseases, presents a formidable challenge in clinical settings due to the extensive toxic side …

Bictegravir, a key second-generation integrase strand transfer inhibitor in the treatment of
HIV, is subject to active efflux transport mediated by ABCB1 (P-glycoprotein). Several coding …

Refractoriness to the pharmacological treatment of cancer is dependent on the expression
levels of genes involved in mechanisms of chemoresistance and on the existence of genetic …

The human ABCB1 protein,(P-glycoprotein or MDR1) is a membrane-bound glycoprotein
that harnesses the energy of ATP hydrolysis to drive the unidirectional transport of …

We used positron emission tomography (PET) to evaluate the contribution of P‐glycoprotein
(P‐gp), present at the human blood–brain barrier (BBB), to regional drug distribution in the …

Objective ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-
glycoprotein, is an efflux protein implicated in the absorption and the distribution of various …