Virtual clinical trials in medical imaging: a review

E Abadi, WP Segars, BMW Tsui… - Journal of Medical …, 2020 - spiedigitallibrary.org
The accelerating complexity and variety of medical imaging devices and methods have
outpaced the ability to evaluate and optimize their design and clinical use. This is a …

DukeSim: a realistic, rapid, and scanner-specific simulation framework in computed tomography

E Abadi, B Harrawood, S Sharma… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
The purpose of this study was to develop a CT simulation platform that is: 1) compatible with
voxel-based computational phantoms; 2) capable of modeling the geometry and physics of …

A scanner-specific framework for simulating CT images with tube current modulation

G Jadick, E Abadi, B Harrawood… - Physics in Medicine …, 2021 - iopscience.iop.org
Although tube current modulation (TCM) is routinely implemented in modern computed
tomography (CT) scans, no existing CT simulator is capable of generating realistic images …

The stochastic digital human is now enrolling for in silico imaging trials—methods and tools for generating digital cohorts

A Badano, MA Lago, E Sizikova… - Progress in …, 2023 - iopscience.iop.org
Randomized clinical trials, while often viewed as the highest evidentiary bar by which to
judge the quality of a medical intervention, are far from perfect. In silico imaging trials are …

Phase-contrast virtual chest radiography

I Häggmark, K Shaker, S Nyrén… - Proceedings of the …, 2023 - National Acad Sciences
Respiratory X-ray imaging enhanced by phase contrast has shown improved airway
visualization in animal models. Limitations in current X-ray technology have nevertheless …

Virtual imaging trials for coronavirus disease (COVID-19)

E Abadi, W Paul Segars, H Chalian… - American Journal of …, 2021 - Am Roentgen Ray Soc
OBJECTIVE. The virtual imaging trial is a unique framework that can greatly facilitate the
assessment and optimization of imaging methods by emulating the imaging experiment …

Synthetic 4DCT (MRI) lung phantom generation for 4D radiotherapy and image guidance investigations

A Duetschler, G Bauman, O Bieri, PC Cattin… - Medical …, 2022 - Wiley Online Library
Purpose Respiratory motion is one of the major challenges in radiotherapy. In this work, a
comprehensive and clinically plausible set of 4D numerical phantoms, together with their …

Development of a scanner-specific simulation framework for photon-counting computed tomography

E Abadi, B Harrawood, JR Rajagopal… - Biomedical physics …, 2019 - iopscience.iop.org
The aim of this study was to develop and validate a simulation platform that generates
photon-counting CT images of voxelized phantoms with detailed modeling of manufacturer …

MRXCAT2. 0: Synthesis of realistic numerical phantoms by combining left-ventricular shape learning, biophysical simulations and tissue texture generation

S Buoso, T Joyce, N Schulthess, S Kozerke - Journal of Cardiovascular …, 2023 - Springer
Background Standardised performance assessment of image acquisition, reconstruction
and processing methods is limited by the absence of images paired with ground truth …

Photon-counting CT versus conventional CT for COPD quantifications: intra-scanner optimization and inter-scanner assessments using virtual imaging trials

S Sotoudeh-Paima, WP Segars… - … 2022: Physics of …, 2022 - spiedigitallibrary.org
CT imaging has proved to be an effective tool in evaluating COPD patients. The
development of photon-counting detectors has offered better spatial resolution and reduced …