[HTML][HTML] The microfluidic environment reveals a hidden role of self-organizing extracellular matrix in hepatic commitment and organoid formation of hiPSCs

F Michielin, GG Giobbe, C Luni, Q Hu, I Maroni… - Cell Reports, 2020 - cell.com
The specification of the hepatic identity during human liver development is strictly controlled
by extrinsic signals, yet it is still not clear how cells respond to these exogenous signals by …

Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects

T Agarwal, V Onesto, L Lamboni, A Ansari… - Bio-Design and …, 2021 - Springer
Conventional 2D intestinal models cannot precisely recapitulate biomimetic features in vitro
and thus are unsuitable for various pharmacokinetic applications, development of disease …

Materials and microenvironments for engineering the intestinal epithelium

J Snyder, CM Wang, AQ Zhang, Y Li, J Luchan… - Annals of Biomedical …, 2020 - Springer
The barrier functions of the gastrointestinal tract rely in large part on a single layer of
columnar intestinal epithelial cells. These epithelial cells are mediators of intestinal …

Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels

KA Wodzanowski, SE Cassel, CL Grimes… - Bioorganic & medicinal …, 2020 - Elsevier
Healthy function of the gut microenvironment is dependent on complex interactions between
the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding …

Engineered 3D Matrices with Spatiotemporally Tunable Properties

K Uto, R Tanimoto, CA DeForest - 2022 - books.rsc.org
It has become widely appreciated that mechanical forces are ever present between cells
and their surroundings and that these forces provide a crucial set of cellular signals that can …