A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …

In endoreplication cell cycles, known as endocycles, cells successively replicate their
genomes without segregating chromosomes during mitosis and thereby become polyploid …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Notch and its ligands are modified by a protein O-fucosyltransferase (OFUT1) that attaches
fucose to a Serine or Threonine within EGF domains. By using RNAi to decrease Ofut1 …

To battle adverse internal and external conditions and maintain homeostasis, diploid
organisms employ various cellular processes, such as proliferation and apoptosis. In some …

Epithelial cells use a striking array of morphogenetic behaviors to sculpt organs and body
plans during development. Although it is clear that epithelial morphogenesis is largely …

The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-
associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or …

Signaling through the transmembrane receptor Notch is widely used throughout animal
development and is a major regulator of cell proliferation and differentiation. During …