Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

The evolution of complex nervous systems in vertebrates has been accompanied by, and
probably dependent on, the acquisition of the myelin sheath. Although there has been …

The energetics of CNS white matter are poorly understood. We derive a signaling energy
budget for the white matter (based on data from the rodent optic nerve and corpus callosum) …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

In myelinated axons, K+ channels are concealed under the myelin sheath in the
juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin …

Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide
galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically …

Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24: 1n-
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …

Fast-transmitting vertebrate axons are electrically insulated with multiple layers of
nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane …

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated
sodium and potassium channels. These channels must be specifically localized to nodes of …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …