A key goal of biology is to understand phenotypic characteristics, such as health, disease
and evolutionary fitness. Phenotypic variation is produced through a complex web of …

In a now classic paper published in 1991, Alberch introduced the concept of genotype–
phenotype (G→ P) mapping to provide a framework for a more sophisticated discussion of …

We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite
abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

SUMMARY A major part of organismal complexity and versatility of prokaryotes resides in
their ability to fine-tune gene expression to adequately respond to internal and external …

Phenotypic heterogeneity is very common in genetic systems and in human diseases and
has important consequences for disease diagnosis and treatment. In addition to the many …

Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration.
We demonstrate that this involves particularly profound transcriptomic alterations where …

Macrophages have been implicated in the pathogenesis of classical Hodgkin lymphoma
(cHL) and have been suggested to have a negative impact on outcome. Most studies …

Non-additive interactions between mutations occur extensively and also change across
conditions, making genetic prediction a difficult challenge. To better understand the plasticity …

Background Many difficult problems in evolutionary genomics are related to mutations that
have weak effects on fitness, as the consequences of mutations with large effects are often …