Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …

As we stand on the brink of the post-antibiotic era, we are in dire need of novel antimicrobial
compounds. Microorganisms produce a wealth of so-called secondary metabolites and have …

Tetracyclines are a class of antibiotics that exhibited potent activity against a wide range of
Gram-positive and Gram-negative bacteria, yet only five members were isolated from …

Lignocellulose wastes stemming from agricultural residues can offer an excellent
opportunity as alternative energy solutions in addition to fossil fuels. Besides, the …

Culture-independent metagenomic approaches offer a promising solution to the discovery of
therapeutically relevant compounds such as antibiotics by enabling access to the hidden …

Advances in metagenomics analysis with the advent of next-generation sequencing have
extended our knowledge of microbial communities as compared to conventional techniques …

Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse
structures. They are an important and fertile source for developing novel drugs. As one of the …

Novel antibiotics are in constant demand to combat a global increase in antibiotic-resistant
infections. Bacterial natural products have been a long-standing source of antibiotic …

Our understanding of the role of secondary metabolites in microbial communities is
challenged by intrinsic limitations of culturing bacteria under laboratory conditions and …

Novel natural products (NPs) and their derivatives are important sources for drug discovery,
which have been broadly applied in the fields of agriculture, livestock, and medicine, making …