Cholesterol is an essential component of eukaryotic cellular membranes. Information about
its subcellular localization and transport pathways inside cells are key for the understanding …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Organelles are physically connected by membrane contact sites. The endoplasmic reticulum
possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins …

Background Genetic background plays an important role in the occurrence and
development of gastric cancer (GC). With the application of genome-wide association study …

Intracellular bacterial pathogens inject effector proteins to hijack host cellular processes and
promote their survival and proliferation. To systematically map effector-host protein-protein …

Tight junctions (TJs) are cell-adhesion structures responsible for the epithelial barrier. We
reported that accumulation of cholesterol at the apical junctions is required for TJ formation …

Introduction Alzheimer's disease remains the most common neurodegenerative disorder,
depicted mainly by memory loss and the presence in the brain of senile plaques and …

Cholesterol mediates membrane compartmentalization, affecting signaling via differential
distribution of receptors and signaling mediators. While excessive cholesterol and aberrant …

Extracellular vesicles such as exosomes are now recognized as key players in intercellular
communication. Their role is influenced by the specific repertoires of proteins and lipids …

Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic
safeguards against auto-immunity and for promoting immunogenic responses to pathogens …