The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK
(extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many …

▪ Abstract Ubiquitin regulates protein transport between membrane compartments by serving
as a sorting signal on protein cargo and by controlling the activity of trafficking machinery …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

Simple Summary Cutaneous melanoma represents the most aggressive form of skin cancer
and its occurrence, development, and progression are based on the accumulation of several …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

Ligand-induced activation of transmembrane receptors activates intracellular signaling
cascades that control vital cellular processes, such as cell proliferation, differentiation …

Fibroblast growth factors (FGF) are secreted molecules which function through the activation
of specific tyrosine kinases receptors, the FGF receptors that transduce the signal by …

Growth factors enable cells to escape irradiation-induced death (apoptosis). One important
family of growth factors share an epidermal growth factor motif, and all bind to ErbB …