Neurogenic orthostatic hypotension is a highly prevalent and disabling feature of autonomic
failure due to both peripheral and central neurodegenerative diseases. Community-based …

The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of
patients, have a profound negative impact on their quality of life, and often go undiagnosed …

Background Leucine‐rich repeat kinase 2 (LRRK2) inhibition is a promising therapeutic
approach for the treatment of Parkinson's disease (PD). Objective The aim of this study was …

Orthostatic hypotension (OH) is frequent in patients with Parkinson's disease (PD) and can
occur with or without symptoms. Pharmacological treatments are effective, but often …

Neurogenic orthostatic hypotension (nOH) results from failure of norepinephrine responses
to postural change to maintain standing systolic blood pressure (s‐SBP). Droxidopa is an …

Neurogenic orthostatic hypotension, postprandial hypotension and exercise-induced
hypotension are common features of cardiovascular autonomic failure. Despite the serious …

Orthostatic hypotension and cognitive impairment are common in Parkinson's disease (PD)
and significantly impair quality of life. Orthostatic hypotension and cognitive impairment …

Background and Objectives Orthostatic hypotension (OH) increases dementia risk in
patients with Parkinson disease (PD), although the underlying mechanisms and whether a …

Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are
characterised by abnormal neuroglial α-synuclein accumulation. These α-synucleinopathies …

Autonomic nervous system involvement occurs at early stages in both Parkinson's disease
(PD) and incidental Lewy body disease (ILBD), and affects the sympathetic …