It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …

The human genome folds to create thousands of intervals, called" contact domains," that
exhibit enhanced contact frequency within themselves." Loop domains" form because of …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

Biomolecular simulation is increasingly central to understanding and designing biological
molecules and their interactions. Detailed, physics‐based simulation methods are …

Mechanically sensitive tissues (eg, skeletal muscles) greatly need mechanical stimuli during
the development and maturation. The extracellular matrix (ECM) mediates these signals …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Remodelling of chromatin architecture is known to regulate gene expression and has been
well characterized in cell lineage development but less so in response to cell perturbation …

Eukaryotic cells must fit meters of DNA into micron-sized cell nuclei and, at the same time,
control and modulate the access to the genetic material. The necessary amount of DNA …

A longstanding hypothesis is that chromatin fiber folding mediated by interactions between
nearby nucleosomes represses transcription. However, it has been difficult to determine the …