Multiscale profiling of protease activity in cancer

AP Amini, JD Kirkpatrick, CS Wang, AM Jaeger… - Nature …, 2022 - nature.com
Diverse processes in cancer are mediated by enzymes, which most proximally exert their
function through their activity. High-fidelity methods to profile enzyme activity are therefore …

Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system

L Hao, N Boehnke, SK Elledge… - Proceedings of the …, 2024 - National Acad Sciences
RNA interference (RNAi) therapeutics are an emerging class of medicines that selectively
target mRNA transcripts to silence protein production and combat disease. Despite the …

Host protease activity classifies pneumonia etiology

M Anahtar, LW Chan, H Ko, A Rao… - Proceedings of the …, 2022 - National Acad Sciences
Community-acquired pneumonia (CAP) has been brought to the forefront of global health
priorities due to the COVID-19 pandemic. However, classification of viral versus bacterial …

A dual-protease-triggered chemiluminescent probe for precise tumor imaging

Z Zhang, R Sun, C Bian, H Wang, Z Zhao, P Lv… - Chinese Chemical …, 2025 - Elsevier
Imaging detection of interlinked dual proteases is imperative for precise tumor imaging,
which remains challenging due to limited modification position of specific substrate and …

[HTML][HTML] Proteolysis of the pericellular matrix: Pinpointing the role and involvement of matrix metalloproteinases in early osteoarthritic remodeling

M Danalache, F Umrath, R Riester, M Schwitalle… - Acta Biomaterialia, 2024 - Elsevier
The pericellular matrix (PCM) serves a critical role in signal transduction and
mechanoprotection in chondrocytes. Osteoarthritis (OA) leads to a gradual deterioration of …

缫丝废水发酵产蛋白酶的菌种筛选及发酵工艺优化.

覃宝山, 付跃, 何海燕, 覃拥灵 - Feed Research, 2023 - search.ebscohost.com
试验旨在研究筛选菌株发酵缫丝废水生产蛋白酶. 试验从自然环境取样, 筛选得到能利用缫丝
废水发酵产蛋白酶的菌株Z416, 形态学观察和分子生物学鉴定该菌株为硝基愈创木胶类节杆菌 …

Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics

Q Zhong, EKW Tan, A Shyamal, C Ngambenjawong… - bioRxiv, 2024 - biorxiv.org
Macromolecular therapeutics designed for intracellular targets must overcome systemic
delivery barriers, target cell membrane impermeability, and inefficient endosomal escape …

Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes

ST Wang, M Anahtar, DM Kim, TS Samad, CM Zhang… - bioRxiv, 2024 - biorxiv.org
Breath biopsy is emerging as a rapid and non-invasive diagnostic tool that links exhaled
chemical signatures with specific medical conditions. Despite its potential, clinical translation …

[引用][C] Engineering modular logic gate-based biomaterial for environmentally triggered CRISPR delivery

S Banskota, BD Center, L Hao, T Lead