[HTML][HTML] Mitochondrial optic neuropathies–disease mechanisms and therapeutic strategies

P Yu-Wai-Man, PG Griffiths, PF Chinnery - Progress in retinal and eye …, 2011 - Elsevier
Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …

Scleral thickness in human eyes

S Vurgese, S Panda-Jonas, JB Jonas - PloS one, 2012 - journals.plos.org
Purpose To obtain information about scleral thickness in different ocular regions and its
associations. Methods The histomorphometric study included 238 human globes which had …

Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism

JC Downs, MD Roberts, IA Sigal - Experimental eye research, 2011 - Elsevier
The purpose of this review is to examine the literature in an attempt to elucidate a
biomechanical basis for glaucomatous cupping. In particular, this work focuses on the role of …

Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma

RE Norman, JG Flanagan, IA Sigal, SMK Rausch… - Experimental eye …, 2011 - Elsevier
Scleral thickness, especially near the optic nerve head (ONH), is a potential factor of interest
in the development of glaucomatous optic neuropathy. Large differences in the dimensions …

Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma

SC Park, CGV De Moraes, CC Teng, C Tello… - Ophthalmology, 2012 - Elsevier
OBJECTIVE: To assess the usefulness of enhanced depth imaging (EDI) optical coherence
tomography (OCT) for evaluating deep structures of the optic nerve complex (ONC; optic …

[HTML][HTML] Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma

H Yang, G Williams, JC Downs, IA Sigal… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: To quantify the lamina cribrosa insertion into the peripapillary sclera and optic
nerve pia in normal (N) and early experimental glaucoma (EEG) monkey eyes. Methods …

IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models

IA Sigal, H Yang, MD Roberts… - … & visual science, 2011 - iovs.arvojournals.org
Purpose.: To study the anterior–posterior lamina cribrosa deformation (LCD) and the scleral
canal expansion (SCE) produced by an increase in IOP and identify the main factors and …

[HTML][HTML] Optical coherence tomography of the swollen optic nerve head: deformation of the peripapillary retinal pigment epithelium layer in papilledema

MJ Kupersmith, P Sibony, G Mandel… - … & visual science, 2011 - jov.arvojournals.org
Purpose.: To examine the biomechanical deformation of load bearing structures of the optic
nerve head (ONH) resulting from raised intracranial pressure, using high definition optical …

Eye-specific IOP-induced displacements and deformations of human lamina cribrosa

IA Sigal, JL Grimm, NJ Jan, K Reid… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: To measure high-resolution eye-specific displacements and deformations induced
within the human LC microstructure by an acute increase in IOP. Methods.: Six eyes from …