Iron transport in the plasma is carried out by transferrin, which donates iron to cells through
its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble …

Recent molecular studies of fetal hemoglobin (HbF) regulation have reinvigorated the field
and shown promise for the development of clinical HbF inducers to be used in patients with …

The aim of this prospective study was to evaluate the long-term efficacy and safety of
hydroxyurea (HU) in patients with sickle cell disease (SCD). Thirty-four patients with sickle …

Background: Hydroxyurea is the only approved drug for treatment of sickle cell disease.
Objective: To synthesize the published literature on the efficacy, effectiveness, and toxicity of …

The past five decades have seen an improvement in the mortality and morbidity of sickle cell
disease (SCD) because of prophylaxis against infectious complications, improved and …

Review Page 1 Review THE ROLE OF HYDROXYUREA IN SICKLE CELL DISEASE
Although the molecular basis for the sickling disorders was identified more than 50 years …

Certain geographic locations, such as Jamaica, have reported a high incidence of sickle cell
leg ulcers (75%); countries such as Saudi Arabia have reported almost zero incidence. 1, 17 …

Leg ulceration is now recognized as an important complication of sickle cell disease,
especially of the SS genotype. Since there is no convincing evidence of delayed healing of …

The National Toxicology Program (NTP) and the National Institute of Environmental Health
Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human …

There is clinical variability in the presentation of sickle cell disease among Indians. Vaso-
occlusive crisis is common among non-tribal patients. Hydroxyurea, induces fetal …