Rare loss of function variants in DSP, which codes for the desmosomal protein desmoplakin,
have been implicated in dilated and arrhythmogenic right ventricular cardiomyopathies. We …

We have performed 280 μ s of unbiased molecular dynamics (MD) simulations to investigate
the effects of 12 different cancer mutations on Kelch-like ECH-associated protein 1 …

Desmoplakin (DSP) is a large (~ 260 kDa) protein found in the desmosome, the subcellular
structure that links the intermediate filament network of one cell to its neighbor. A mutation …

Desmosomes are cell-cell junctions that maintain the integrity of tissues that experience
significant mechanical stress, such as the skin and heart. Desmosomal plaque proteins are …

Arrhythmias account for approximately 250,000 deaths in the US annually, with nearly half
being associated with heart disease. Arrhythmogenic disorders are broken down into a …