This article reviews the development of bifunctional chelates for synthesising 68 Ga
radiopharmaceuticals. It structures the chelates into groups of macrocycles …

The importance of iron chelators in medicine has significantly increased in recent years. Iron
is essential for life but it is also potentially more toxic than other trace elements. This is …

68Ge/68Ga radionuclide generators have been investigated for almost fifty years now, since
the cyclotronindependent availability of positron emitting 68Ga via the 68Ge/68Ga system …

Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone)
ligands - Chemical Communications (RSC Publishing) DOI:10.1039/C1CC12123E Royal …

In recent years, Positron Emission Tomography (PET) has become a practical, high
performance clinical imaging modality for visualization of biological process within the living …

Hydroxypyridinones (HPs) are a family of N-heterocyclic core chelators which, based on
their specific metal-coordination, easy manipulation/derivatization and biocompatibility, have …

The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly
versatile class of ligands. The most widely investigated for medicinal applications are the 3 …

Hydroxypyridinones (HOPOs) form outstanding building blocks for the development of a
variety of agents in the field of metal chelation. The pyridinone ring is easily synthesized and …

Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β+, Emax=
897 keV, Eav= 397 keV, Eγ= 909 keV, Iγ= 100%) 89Zr is an appealing radionuclide for …

Pyrone scaffolds are often present in natural products and many derivatives therefore exhibit
favorable biocompatibility and toxicity profiles. Hydroxypyrones are obtained from natural …