NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Adipokines in non-alcoholic fatty liver disease: are we on the road toward new biomarkers and therapeutic targets?

V Francisco, MJ Sanz, JT Real, P Marques… - Biology, 2022 - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is an unmet medical need due to
its increasingly high incidence, severe clinical consequences, and the absence of feasible …

[HTML][HTML] Hepatokines and adipokines in NASH-related hepatocellular carcinoma

O Kucukoglu, JP Sowa, GD Mazzolini, WK Syn… - Journal of …, 2021 - Elsevier
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Relationship between oxidative stress, inflammation and dyslipidemia with fatty liver index in patients with type 2 diabetes mellitus

A Klisic, A Isakovic, G Kocic, N Kavaric… - Experimental and …, 2018 - thieme-connect.com
Introduction/Aim Considering the high prevalence of non-alcoholic fatty liver disease
(NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the …

Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives

F Wen, G Gui, X Wang, L Ye, A Qin, C Zhou… - Bioorganic & Medicinal …, 2024 - Elsevier
Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the
nicotinamide adenine dinucleotide (NAD+) salvage pathway, primarily catalyzing the …

Serum visfatin levels in nonalcoholic fatty liver disease and liver fibrosis: systematic review and meta-analysis

A Ismaiel, DC Leucuta, SL Popa… - Journal of clinical …, 2021 - mdpi.com
(1) Background: Recently, adipokines, including visfatin, have been studied in nonalcoholic
fatty liver disease (NAFLD). Several studies evaluated visfatin levels in NAFLD, the …

IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis: an integrated bioinformatics and experimental study

X Chen, Y Tang, S Chen, W Ling… - Endocrine …, 2021 - ec.bioscientifica.com
Background and aims Non-alcoholic fatty liver disease (NAFLD) has become a common
chronic liver disease in the world. Simple steatosis (SS) is the early phase of NAFLD …

Nicotinamide and NAFLD: is there nothing new under the sun?

M Guarino, JF Dufour - Metabolites, 2019 - mdpi.com
Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and
energy homeostasis. Its importance has been established early with the discovery of NAD's …

[HTML][HTML] Nicotinamide phosphoribosyltransferase knockdown leads to lipid accumulation in HepG2 cells through the SIRT1-AMPK pathway

D Ilbeigi, M Nourbakhsh, P Pasalar… - Cell Journal …, 2020 - ncbi.nlm.nih.gov
Objective Nicotinamide phosphoribosyltransferase (NAMPT), which is responsible for
biosynthesis of nicotinamide adenine dinucleotide (NAD), has a regulatory role in cellular …

NAD metabolic therapy in Metabolic dysfunction-associated steatotic liver disease: possible roles of gut microbiota

X Lu, R Yang, Y Chen, D Chen - Iscience, 2024 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly named Non-
alcoholic fatty liver disease (NAFLD), is induced by alterations of hepatic metabolism. As a …