E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
O Thews, A Riemann - Cancer and Metastasis Reviews, 2019 - Springer
Tumors often show, compared to normal tissues, a markedly decreased extracellular pH resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …
SM Hill, VP Belancio, RT Dauchy… - Endocrine-related …, 2015 - erc.bioscientifica.com
The present review discusses recent work on melatonin-mediated circadian regulation, the metabolic and molecular signaling mechanisms that are involved in human breast cancer …
MRK Ali, Y Wu, Y Tang, H Xiao… - Proceedings of the …, 2017 - National Acad Sciences
Metastasis is responsible for most cancer-related deaths, but the current clinical treatments are not effective. Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell …
Z Wang, M Snyder, JE Kenison, K Yang, B Lara… - International Journal of …, 2020 - mdpi.com
For decades, the aryl hydrocarbon receptor (AHR) was studied for its role in environmental chemical toxicity ie, as a quirk of nature and a mediator of unintended consequences of …
M Babiceanu, F Qin, Z Xie, Y Jia, K Lopez… - Nucleic acids …, 2016 - academic.oup.com
Gene fusions and their products (RNA and protein) were once thought to be unique features to cancer. However, chimeric RNAs can also be found in normal cells. Here, we performed …
RL Pearlman, MKM de Oca, HC Pal, F Afaq - Cancer letters, 2017 - Elsevier
Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal …
IV Bure, MV Nemtsova, DV Zaletaev - International journal of molecular …, 2019 - mdpi.com
The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and metastatic cancer cell spreading. E-cadherin is an important player in this process, which …