Reframing sexual differentiation of the brain

MM McCarthy, AP Arnold - Nature neuroscience, 2011 - nature.com
In the twentieth century, the dominant model of sexual differentiation stated that genetic sex
(XX versus XY) causes differentiation of the gonads, which then secrete gonadal hormones …

Etiologies underlying sex differences in autism spectrum disorders

SM Schaafsma, DW Pfaff - Frontiers in neuroendocrinology, 2014 - Elsevier
The male predominance of Autism Spectrum Disorders (ASD) is one of the best-known, and
at the same time, one of the least understood characteristics of these disorders. In this paper …

Microglia are essential to masculinization of brain and behavior

KM Lenz, BM Nugent, R Haliyur… - Journal of …, 2013 - Soc Neuroscience
Brain sexual differentiation in rodents results from the perinatal testicular androgen surge. In
the preoptic area (POA), estradiol aromatized from testosterone upregulates the production …

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

VS Ratnu, MR Emami, TW Bredy - Journal of neuroscience …, 2017 - Wiley Online Library
There are inherent biological differences between males and females that contribute to sex
differences in brain function and to many sex‐specific illnesses and disorders. Traditionally …

Sexual differentiation of the rodent brain: dogma and beyond

KM Lenz, BM Nugent, MM McCarthy - Frontiers in neuroscience, 2012 - frontiersin.org
Steroid hormones of gonadal origin act on the neonatal brain to produce sex differences that
underlie adult reproductive physiology and behavior. Neuronal sex differences occur on a …

Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility

IA Qureshi, MF Mehler - Progress in brain research, 2010 - Elsevier
There are numerous examples of sex differences in brain and behavior and in susceptibility
to a broad range of brain diseases. For example, gene expression is sexually dimorphic …

The proteomic landscape of sperm surface deciphers its maturational and functional aspects in buffalo

V Batra, K Dagar, MP Diwakar, A Kumaresan… - Frontiers in …, 2024 - frontiersin.org
Buffalo is a dominant dairy animal in many agriculture-based economies. However, the poor
reproductive efficiency (low conception rate) of the buffalo bulls constrains the realization of …

Hormone-dependent medial preoptic/lumbar spinal cord/autonomic coordination supporting male sexual behaviors

DW Pfaff, MJ Baum - Molecular and Cellular Endocrinology, 2018 - Elsevier
Testosterone (T) can act directly through neural androgen receptors (AR) to facilitate male
sexual behavior; however, T's metabolites also can play complicated and interesting roles in …

Maintenance of sexual activity following androgen deprivation in males

CJ Duthie, HJ Calich, CM Rapsey, E Wibowo - Critical Reviews in …, 2020 - Elsevier
Androgen deprivation therapy (ADT) is a common treatment for men with systemic prostate
cancer. However, ADT leads to sexual dysfunction, causing> 80% of couples to cease …

Glutamate in male and female sexual behavior: Receptors, transporters, and steroid independence

VSC Chiang, JH Park - Frontiers in behavioral neuroscience, 2020 - frontiersin.org
The survival of animal species predicates on the success of sexual reproduction.
Neurotransmitters play an integral role in the expression of these sexual behaviors in the …