One of the principal goals of cancer immunotherapy is the development of efficient
therapeutic cancer vaccines that are able to elicit an effector as well as memory T cell …

Computational vaccinology includes epitope mapping, antigen selection, and immunogen
design using computational tools. Tools that facilitate the in silico prediction of immune …

Immune responses to protein and peptide drugs can alter or reduce their efficacy and may
be associated with adverse effects. While anti-drug antibodies (ADA) are a standard clinical …

Protein therapeutics have drastically changed the landscape of treatment for many diseases
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …

Introduction The field of cancer therapy has undergone a major transformation in less than a
decade due to the introduction of checkpoint inhibitors, the advent of next generation …

Computational vaccine design, also known as computational vaccinology, encompasses
epitope mapping, antigen selection and immunogen design using computational tools. The …

Efanesoctocog alfa (Altuviiio, TM Sanofi-SOBI) is a B domain-deleted single-chain Factor VIII
(FVIII) connected to D'D3 domain of von Willebrand Factor (vWF). Its ingenious design …

Peptide drugs play an important part in medicine owing to their many therapeutic
applications. Of the 80 peptide drugs approved for use in humans, at least five are now off …

ABSTRACT A potential risk factor for immunogenicity of a biotherapeutic is the low levels of
host cell protein (HCP) impurities that remain in the product following the purification …

In silico immunogenicity risk assessment has been an important step in the development
path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a …