Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is
associated with systemic hyperinflammatory response and immunopathology. Although …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Cellular growth, function, and protection require proper iron management, and ferritin plays
a crucial role as the major iron sequestration and storage protein. Ferritin is a 24 subunit …

New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …

Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It
plays a crucial role in various metabolic pathways, inflammation processes, stress response …

Site-specific Fe 2+ generation is promising for tumor therapy. Up to now, reported materials
or systems for Fe 2+ delivery do not naturally exist in the body, and their biological safety …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

Ferritin, an iron-storage protein, regulates cellular iron metabolism and oxidative stress. The
ferritin structure is characterized as a spherical cage, inside which large amounts of iron are …