Highlights•Flower development requires de novo formation of a stem cell niche.•Auxin and
cytokinin signaling interact to trigger emergence of floral meristems.•Meristem growth and …

Robust temporal and spatial patterns of cell types emerge in the course of normal
development in multicellular organisms. The onset of degenerative diseases may result from …

The logical formalism is well adapted to model large cellular networks, in particular when
detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative …

Purpose: We put forward a theoretical and dynamical approach for the semi-quantitative
analysis of CD4+ T cell differentiation, the process by which cells with different functions are …

The balance between cell growth, proliferation, and differentiation emerges from gene
regulatory networks coupled to various signal transduction pathways, including reactive …

In rice, inflorescence architecture is established at early stages of reproductive development
and contributes directly to grain yield potential. After induction of flowering, the complexity of …

Post-embryonic plant development is characterized by a period of vegetative growth during
which a combination of intrinsic and extrinsic signals triggers the transition to the …

Background Tumorigenic transformation of human epithelial cells in vitro has been
described experimentally as the potential result of spontaneous immortalization. This …

Biology relies on the central thesis that the genes in an organism encode molecular
mechanisms that combine with stimuli and raw materials from the environment to create a …

Background Gene regulatory network (GRN) dynamical models are standard systems
biology tools for the mechanistic understanding of developmental processes and are …