Genomic instability is a hallmark of cancer cells which results in excessive DNA damage. To
counteract this, cells have evolved a tightly regulated DNA damage response (DDR) to …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are
unusually diverse with regard to their chromatin features, including histone modifications …

Hepatocyte nuclear factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent
studies have highlighted its role in inhibition of hepatocyte proliferation and tumor …

Background Plant homeodomain (PHD) fingers are central “readers” of histone post-
translational modifications (PTMs) with> 100 PHD finger-containing proteins encoded by the …

Introduction PROTACs represent a novel class of heterobifunctional molecules that
simultaneously bind to a target protein and to an E3 ligase complex, resulting in the transfer …

Abstract Background Glioblastoma stem cells (GSCs) are a subpopulation of glioblastoma
(GBM) cells that are critical for tumor invasion and treatment resistance. However, little is …

Novel therapeutic options are urgently needed to improve the global treatment of viral
infections. Tripartite motif (TRIM) family proteins are involved in various biological and …

The epigenetic machinery deputed to control histone post-translational modifications is
frequently dysregulated in cancer cells. With epigenetics being naturally reversible, it …

Ubiquitination is a post-translational modification that has pivotal roles in protein
degradation and diversified cellular processes, and for more than two decades it has been a …