Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50
million people worldwide with an estimated increase to 139 million people by 2050. The …

Autophagy is a cellular innate-immune defence mechanism against intracellular
microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non …

Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated
on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD) …

The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2)
regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function …

There is increasing genetic evidence for the role of microglia in neurodegenerative
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …

Genetic findings have highlighted key roles for microglia in the pathology of
neurodegenerative conditions such as Alzheimer's disease (AD). A number of mutations in …

The central role of the resident innate immune cells of the brain (microglia) in
neurodegeneration has become clear over the past few years largely through genome-wide …

Cholesterol homeostasis is impaired in Alzheimer's disease; however, attempts to modulate
brain cholesterol biology have not translated into tangible clinical benefits for patients to …

Both astrocytes and microglia fulfil homeostatic and immune functions in the healthy CNS.
Dysfunction of these cell types have been implicated in the pathomechanisms of several …