Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …

RNA-binding proteins (RBPs) are critical players in RNA expression and metabolism, thus,
the proper regulation of this class of proteins is critical for cellular health. Regulation of RBPs …

Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression
of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory …

Mutations in the RNA-binding protein (RBP) FUS have been genetically associated with the
motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced …

Liquid–liquid phase separation results in the formation of dynamic biomolecular
condensates, also known as membrane-less organelles, that allow for the assembly of …

Neuronal homeostasis requires the transport of various organelles to distal compartments
and defects in this process lead to neurological disorders. Although several mechanisms for …

Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …

RNA granules are dynamic entities controlling the spatiotemporal distribution and translation
of RNA molecules. In neurons, a variety of RNA granules exist both in the soma and in …

RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and
maintain proteome homeostasis. RNA binding proteins, translation factors, and cell …