Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Emerging new therapeutic antibody derivatives for cancer treatment

S Jin, Y Sun, X Liang, X Gu, J Ning, Y Xu… - Signal transduction and …, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …

Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Neoantigen: A new breakthrough in tumor immunotherapy

Z Zhang, M Lu, Y Qin, W Gao, L Tao, W Su… - Frontiers in …, 2021 - frontiersin.org
Cancer immunotherapy works by stimulating and strengthening the body's anti-tumor
immune response to eliminate cancer cells. Over the past few decades, immunotherapy has …

Antibody–drug conjugates for cancer therapy

U Hafeez, S Parakh, HK Gan, AM Scott - Molecules, 2020 - mdpi.com
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …

Antibody–drug conjugates for cancer

CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …

A paradigm shift in cancer immunotherapy: from enhancement to normalization

MF Sanmamed, L Chen - Cell, 2018 - cell.com
Harnessing an antitumor immune response has been a fundamental strategy in cancer
immunotherapy. For over a century, efforts have primarily focused on amplifying immune …

Phage display derived monoclonal antibodies: from bench to bedside

MA Alfaleh, HO Alsaab, AB Mahmoud… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …