Molecular networks as sensors and drivers of common human diseases
EE Schadt - Nature, 2009 - nature.com
The molecular biology revolution led to an intense focus on the study of interactions
between DNA, RNA and protein biosynthesis in order to develop a more comprehensive …
between DNA, RNA and protein biosynthesis in order to develop a more comprehensive …
Inferring interaction networks from multi-omics data
A major goal in systems biology is a comprehensive description of the entirety of all complex
interactions between different types of biomolecules—also referred to as the interactome …
interactions between different types of biomolecules—also referred to as the interactome …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Targeting BCAA catabolism to treat obesity-associated insulin resistance
M Zhou, J Shao, CY Wu, L Shu, W Dong, Y Liu… - Diabetes, 2019 - Am Diabetes Assoc
Recent studies implicate a strong association between elevated plasma branched-chain
amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and …
amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and …
Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
The lack of high-throughput methods to analyze the adipose tissue protein composition
limits our understanding of the protein networks responsible for age and diet related …
limits our understanding of the protein networks responsible for age and diet related …
Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease
Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …
sets to construct predictive models of IBD. We present a predictive model of the immune …