Understanding the rules of life is one of the most important scientific endeavours and has
revolutionised both biology and biotechnology. Remarkable advances in observation …

The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized.
The historical record is explored from both biochemical and theoretical perspectives …

College, Quincy, IL. His graduate work in physical organic chemistry under Richard L.
Schowen of the University of Kansas Chemistry Department culminated in a Ph. D. degree in …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Most enzymatic reactions have very large and remarkably similar apparent second-order
rate constants, kcat/KM, at mean values of about 107 M-1 s-1 with kcat in the range of 10 …

Publisher Summary This chapter discusses the solvent isotope effects on enzyme systems.
The introduction of deuterium in place of protium in the hydrogenic sites of water, and its …

All chemical transformations pass through an unstable structure called the transition state,
which is poised between the chemical structures of the substrates and products. The …

A number of mutants of mofA, a gene necessary for flagellar rotation in E. coli, were isolated
and characterized. Many mutations were dominant, owing to competition between functional …

Pauling proposed that “enzymes are molecules that are complementary in structure to the
activated complexes of the reactions that they catalyze,...,[rather than] entering into …

The Proton: Applications to Organic Chemistry deals with several aspects of the proton
drawn from organic chemistry. This book begins with an introductory chapter, followed by …