Contribution of Müller cells in the diabetic retinopathy development: Focus on oxidative stress and inflammation

R Carpi-Santos, RA de Melo Reis, FCA Gomes… - Antioxidants, 2022 - mdpi.com
Diabetic retinopathy is a neurovascular complication of diabetes and the main cause of
vision loss in adults. Glial cells have a key role in maintenance of central nervous system …

Metabolomics in retinal diseases: an update

X Li, S Cai, Z He, J Reilly, Z Zeng, N Strang, X Shu - Biology, 2021 - mdpi.com
Simple Summary Visual loss and blindness caused by retinal disease has a significant
negative effect on the quality of life of many adults and children, and as a result has become …

Metabolism and vascular retinopathies: Current perspectives and future directions

C Singh - Diagnostics, 2022 - mdpi.com
The retina is one of the most metabolically active organs in the body. Although it is an
extension of the brain, the metabolic needs of the retina and metabolic exchanges between …

Dual switch mechanism of erythropoietin as an antiapoptotic and pro-angiogenic determinant in the retina

FP Samson, W He, SR Sripathi, AT Patrick, J Madu… - ACS …, 2020 - ACS Publications
Constant or intense light degenerates the retina and retinal pigment epithelial cells. Light
generates reactive oxygen species and nitric oxide leading to initial reactions of retinal …

The complement system and diabetic retinopathy

F Jiang, C Lei, Y Chen, N Zhou, M Zhang - Survey of Ophthalmology, 2024 - Elsevier
Diabetic retinopathy (DR) is one of the common microvascular complications of diabetes
mellitus and is the main cause of visual impairment in diabetic patients. The pathogenesis of …

Prohibitin 1 Regulates Inflammatory Mediators and Reactive Oxygen Species in Retinal Endothelial Cells

L Liu, Y Jiang, JJ Steinle - Journal of Clinical Medicine, 2022 - mdpi.com
Diabetic retinopathy is associated with increased inflammatory mediator levels. In these
studies, we focused on prohibitin 1. We performed western blotting for retinal lysates from …

PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway

F Chen, X Cai, Y Yu - Open Life Sciences, 2024 - degruyter.com
Fibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated
the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by …