Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Aldehydes are organic compounds that are widespread in nature. They can be formed
endogenously by lipid peroxidation (LPO), carbohydrate or metabolism ascorbate …

Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal-
physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome …

Recent progress in the development of molecular cancer therapeutics has revealed new
types of antitumor drugs, such as Herceptin, Gleevec, and Iressa, as potent therapeutics for …

The reactive dicarbonyl metabolite methylglyoxal (MG) is the precursor of the major
quantitative advanced glycation endproducts (AGEs) in physiological systems-arginine …

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to
increased protein and DNA modification contributing to cell and tissue dysfunction in aging …

The receptor tyrosine kinase ErbB2 (HER-2/neu) is overexpressed in up to 30% of breast
cancers and is associated with poor prognosis and an increased likelihood of metastasis …

The reactive advanced glycation end product (AGE) precursor methylglyoxal (MGO) and
MGO-derived AGEs are associated with diabetic vascular complications and also with an …

Epithelial ovarian cancer kills almost 16 000 women each year in part due to late stage of
presentation and lack of reliable biomarkers for disease detection. CA‐125, the currently …