Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

Action mechanisms and research methods of tRNA-derived small RNAs

Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

tRNA-derived RNA fragments in cancer: current status and future perspectives

M Yu, B Lu, J Zhang, J Ding, P Liu, Y Lu - Journal of Hematology & …, 2020 - Springer
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades,
and their fundamental roles in human diseases have been well established. Transfer RNAs …

Deciphering the tRNA-derived small RNAs: origin, development, and future

B Liu, J Cao, X Wang, C Guo, Y Liu, T Wang - Cell Death & Disease, 2021 - nature.com
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …

5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis

Y Wu, X Yang, G Jiang, H Zhang, L Ge, F Chen, J Li… - Genome medicine, 2021 - Springer
Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues
including blood and urine, play an important role in the progression of cancer. However, the …

Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases

Q Weng, Y Wang, Y Xie, X Yu, S Zhang, J Ge… - Journal of Molecular …, 2022 - Springer
Traditionally, transfer RNAs (tRNAs) specifically decoded messenger RNA (mRNA) and
participated in protein translation. tRNA-derived fragments (tRFs), also known as tRNA …

The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway

L Zhu, Z Li, X Yu, Y Ruan, Y Shen, Y Shao… - Stem Cell Research & …, 2021 - Springer
Background Recently, tRNA-derived fragments (tRFs) have been shown to serve important
biological functions. However, the role of tRFs in gastric cancer has not been fully …

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

S Park, J Ham, C Yang, W Park, H Park… - Journal of Pineal …, 2023 - Wiley Online Library
Endometriosis is a benign gynecological disease characterized by abnormal growth of
endometrial‐like cells outside the uterus. Melatonin, a hormone secreted by the pineal …

A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

L Han, H Lai, Y Yang, J Hu, Z Li, B Ma, W Xu… - Journal of Experimental …, 2021 - Springer
Background tRNA-derived small noncoding RNAs (sncRNAs) are mainly categorized into
tRNA halves (tiRNAs) and fragments (tRFs). Biological functions of tiRNAs in human solid …

tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer

D Mo, F He, J Zheng, H Chen, L Tang, F Yan - Frontiers in oncology, 2021 - frontiersin.org
tRNA derivatives have been identified as a new kind of potential biomarker for cancer.
Previous studies have identified that there were 30 differentially expressed tRNAs …