Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Mental fatigue reflects a change in psychobiological state, caused by prolonged periods of
demanding cognitive activity. It has been well documented that mental fatigue impairs …

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

The COVID-19 pandemic has spread worldwide, affecting millions of people and exposing
them to home quarantine, isolation, and social distancing. While recent reports showed …

Shift work increases the risk for human errors, such that drowsiness due to shift work has
contributed to major industrial disasters, including Space Shuttle Challenger, Chernobyl and …

Stable trait-like responding is well established for neurobehavioral performance measures
across repeated exposures to total sleep deprivation and partial chronic sleep restriction …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

Sleep deprivation significantly impairs a range of cognitive and brain function, particularly
episodic memory and the underlying hippocampal function. However, it remains …

Purinergic receptors play important roles in central nervous system (CNS). These receptors
are involved in cellular neuroinflammatory responses that regulate functions of neurons …