Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the
metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which …

Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic
pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced …

Chronic inflammation and pain is a major global health problem, and nonsteroidal anti-
inflammatory drugs (NSAIDs) remain the most frequently prescribed drugs and common …

Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the
endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are …

Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including
epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the …

Neuroinflammation is a crucial process associated with the pathogenesis of
neurodegenerative diseases, including Parkinson's disease (PD). Several pieces of …

Over the last two decades polypharmacology has emerged as a new paradigm in drug
discovery, even though developing drugs with high potency and selectivity toward a single …

Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly
important metabolic enzymes in various tissues, including brain. Although expressions of …