The field of regenerative medicine has progressed tremendously over the past few decades
in its ability to fabricate functional tissue substitutes. Conventional approaches based on …

Frank's Windkessel model described the hemodynamics of the arterial system in terms of
resistance and compliance. It explained aortic pressure decay in diastole, but fell short in …

SUMMARY 1 Artificial heart valves have been in use for over five decades to replace
diseased heart valves. Since the first heart valve replacement performed with a caged‐ball …

Current mechanical conditioning approaches for heart valve tissue engineering concentrate
on mimicking the opening and closing behavior of the leaflets, either or not in combination …

This review describes the current knowledge and applications of pulsatile flow in microfluidic
systems. Elements of fluid dynamics at low Reynolds number are first described in the …

Heart disease is a major cause of death in the Western world. In the past three decades
there has been a number of improvements in artificial devices and surgical techniques for …

Considering the current techniques in cell culture, the stimulation of cellular proliferation and
the formation of bidimensional tissues such as skin are widely performed in academic and …

It is estimated that the number of patients requiring heart valve replacement will triple over
the next five decades. None of the current replacement valves can fully restore native valve …

Our group has previously demonstrated the synthesis of a completely autologous fibrin-
based heart valve structure using the principles of tissue engineering. The present approach …

A scaleable perfusion bioreactor has been developed for tissue engineering of small
diameter arterial constructs. This modular bioreactor allows for dynamic sequential seeding …