Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …

Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …

Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

Adaptation to acid stress is an important factor in the transmission of intestinal microbes. The
enterobacterium Escherichia coli uses a range of physiological, metabolic, and proton …

Secondary active transporters exploit the electrochemical potential of solutes to shuttle
specific substrate molecules across biological membranes, usually against their …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …

The Earth is home to environments characterized by low pH, including the gastrointestinal
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …