Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Among the diseases causing human death, cardiovascular disease (CVD) remains number
one according to the World Health Organization report in 2021. It is known that …

Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …

Background Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …

Diabetes mellitus is a complex disease. We are increasingly gaining a better understanding
of its mechanisms at the molecular level. From these new insights, better therapeutic …

Over the past two decades, it was discovered that introducing synthetic small interfering
RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This …

Background and aims Central and Eastern Europe (CEE) is a largely understudied region,
despite having the highest cardiovascular disease mortality in Europe. This analysis aimed …

Proprotein convertase subtilisin/kexin type-9 (PCSK9), a secreted protein that is synthesized
and spontaneously cleaved in the endoplasmic reticulum, has become a hot lipid-lowering …

Cardiovascular disease is the leading cause of death worldwide, and its prevalence is
increasing due to the aging of societies. Atherosclerosis, a type of chronic inflammatory …