Experimental data indicate that transneuronal propagation of abnormal protein aggregates
in neurodegenerative proteinopathies, such as sporadic Alzheimer's disease (AD) and …

Conjugated oligoelectrolytes (COEs) are a relatively new class of synthetic organic
molecules with, as of yet, untapped potential for use in organic optoelectronic devices and …

The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases,
causing inflammation and changing the inflammatory signature of microglia by unknown …

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell
death in many neurodegenerative diseases. How neurons die in these tauopathies is …

As a key player of the protein quality control network of the cell, the molecular chaperone
Hsp70 inhibits the aggregation of the amyloid protein tau. To date, the mechanism of this …

The ability of small lipophilic molecules to penetrate the blood–brain barrier through
transmembrane diffusion has enabled researchers to explore new diagnostics and therapies …

Background and Objective To characterize morphological and molecular underpinnings of
polymyositis with mitochondrial pathology (PM-Mito) in comparison with sporadic inclusion …

The ordered assembly of amyloidogenic proteins causes a wide spectrum of common
neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. These …

Tau exists as six closely related protein isoforms in the adult human brain. These are
generated from alternative splicing of a single mRNA transcript and they differ in the …

The aberrant misfolding and subsequent conversion of monomeric protein into amyloid
aggregates characterises many neurodegenerative disorders, including Parkinson's and …