Genome-scale metabolic models are widely used to enhance our understanding of
metabolic features of organisms, host-pathogen interactions and to identify therapeutics for …

Gastrointestinal nematodes (GINs) are among the most common parasites of humans,
livestock, and companion animals. GIN parasites infect 1–2 billion people worldwide …

The ascarids are a large group of parasitic nematodes that infect a wide range of animal
species. In humans, they cause neglected diseases of poverty; many animal parasites also …

Drug resistance observed with many anti-infectives clearly highlights the need for new broad-
spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic …

Metabolic rewiring to utilize aerobic glycolysis is a hallmark of cancer. However, recent
findings suggest the role of mitochondria in energy generation in cancer cells and the …

Soil transmitted helminths (STHs) are major human pathogens that infect over a billion
people. Resistance to current anthelmintics is rising and new drugs are needed. Here we …

Abstract Development of direct acting macrofilaricides for the treatment of human filariases is
hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro …

Filarial worms cause multiple debilitating diseases in millions of people worldwide, including
river blindness. Currently available drugs reduce transmission by killing larvae …

The search for new anti-infectives based on metal complexes is gaining momentum. Among
the different options taken by researchers, the one involving the use of organometallic …

Gastrointestinal nematode (GIN) infections are a major concern for the ruminant industry
worldwide and result in significant production losses. Naturally occurring polyparasitism and …