Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies

E Olmastroni, G Molari, N De Beni… - European journal of …, 2022 - academic.oup.com
Aims As the potential impact of statins on cognitive decline and dementia is still debated, we
conducted a meta-analysis of observational studies to examine the effect of statin use on the …

Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism

BA Golomb, MA Evans - American Journal of Cardiovascular Drugs, 2008 - Springer
HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

Statin‐associated adverse cognitive effects: survey results from 171 patients

MA Evans, BA Golomb - Pharmacotherapy: The Journal of …, 2009 - Wiley Online Library
Study Objective. To characterize the adverse cognitive effects of 3‐hydroxy‐3‐methylglutaryl
coenzyme A reductase inhibitors (statins). Design. Patient survey‐based analysis. Patients …

Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations

CH Rojas-Fernandez… - Annals of …, 2012 - journals.sagepub.com
Objective: To explore the impact of statin use on cognition. Data Sources: A literature search
was performed using MEDLINE (1950-November 2011), EMBASE (1980-November 2011) …

An assessment by the statin cognitive safety task force: 2014 update

CH Rojas-Fernandez, LB Goldstein, AI Levey… - Journal of Clinical …, 2014 - Elsevier
Abstract The National Lipid Association's Safety Task Force convened a consensus
conference of experts to develop a position statement on cognitive function to revise and …

Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease

HF Hope, GM Binkley, S Fenton, GD Kitas… - PLoS …, 2019 - journals.plos.org
Introduction Previous research has shown that statin adherence for the primary prevention of
CVD is lower compared to secondary prevention populations. Therefore the aim of this …

Statin therapy and risk of acute memory impairment

BL Strom, R Schinnar, J Karlawish… - JAMA internal …, 2015 - jamanetwork.com
Importance Reports on the association between statins and memory impairment are
inconsistent. Objective To assess whether statin users show acute decline in memory …

Association of statin use with sleep disturbances: data mining of a spontaneous reporting database and a prescription database

M Takada, M Fujimoto, K Yamazaki, M Takamoto… - Drug safety, 2014 - Springer
Background Particular interest has been generated regarding the possible influence of statin
use on sleep quality. However, no conclusive evidence exists that a particular statin is more …

Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced …

AJ McFarland, AK Davey, CM McDermott… - Toxicology and Applied …, 2018 - Elsevier
Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been
associated with conflicting effects within the central nervous system (CNS), with underlying …

Association of statin use with cognitive decline in elderly African Americans

SJ Szwast, HC Hendrie, KA Lane, S Gao, SE Taylor… - Neurology, 2007 - AAN Enterprises
Background: Previously reported associations between statin use and incident dementia or
cognitive decline have been inconsistent. We report the results from a 3-year prospective …