Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

Arachnoid granulations (AG) are poorly investigated. Historical reports suggest that they
regulate brain volume by passively transporting cerebrospinal fluid (CSF) into dural venous …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …

Alzheimer's dementia is a pathologically heterogeneous and biologically multilayered
disease. Recent studies and exercises in nomenclature reveal shortcomings in existing …

Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant
advancement in treating neurological diseases. The BBB is a tightly packed layer of …

The concept of the glymphatic system was proposed more than a decade ago as a
mechanism for interstitial fluid flow and waste removal in the central nervous system. The …

Background: Focused ultrasound (FUS) in combination with microbubbles has recently
shown great promise in facilitating blood-brain barrier (BBB) opening for drug delivery and …

As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …